Abstract
In the neocortex of an aged (26-year-old) rhesus monkey, a small percentage of abnormal neurites within some senile plaques (defined by the presence of amyloid) were immunoreactive for glutamic acid decarboxylase. This suggests that gamma-aminobutyric acid-synthesizing neurons may contribute to plaque formation in the aged brain.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aging*
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Amyloid / metabolism
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Animals
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Cerebral Cortex / enzymology*
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Cerebral Cortex / physiology
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Glutamate Decarboxylase / metabolism*
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Immunoenzyme Techniques
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Macaca mulatta
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Synaptic Transmission
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gamma-Aminobutyric Acid / physiology
Substances
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Amyloid
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gamma-Aminobutyric Acid
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Glutamate Decarboxylase