Extracellular Vesicles and the Application of System Biology and Computational Modeling in Cardiac Repair

Circ Res. 2018 Jul 6;123(2):188-204. doi: 10.1161/CIRCRESAHA.117.311215.


Recent literature suggests that extracellular vesicles (EVs), secreted from most cells and containing cell-specific cargo of proteins, lipids, and nucleic acids, are major driver of intracellular communication in normal physiology and pathological conditions. The recent evidence on stem/progenitor cell EVs as potential therapeutic modality mimicking their parental cell function is exciting because EVs could possibly be used as a surrogate for the stem cell-based therapy, and this regimen may overcome certain roadblocks identified with the use of stem/progenitor cell themselves. This review provides a comprehensive update on our understanding on the role of EVs in cardiac repair and emphasizes the applications of stem/progenitor cell-derived EVs as therapeutics and discusses the current challenges associated with the EV therapy.

Keywords: biology; exosomes; extracellular vesicles; lipids; stem cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / therapy*
  • Extracellular Vesicles / classification
  • Extracellular Vesicles / genetics
  • Extracellular Vesicles / transplantation*
  • Humans
  • MicroRNAs / genetics
  • Stem Cell Transplantation / methods*
  • Systems Biology / methods*


  • MicroRNAs