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Comparative Study
. 2018 Jul 5;23(7):1640.
doi: 10.3390/molecules23071640.

Development of Dermal Films Containing Miconazole Nitrate

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Free PMC article
Comparative Study

Development of Dermal Films Containing Miconazole Nitrate

Magdalena Bîrsan et al. Molecules. .
Free PMC article

Abstract

This study aims to develop new antifungal dermal films based on their mechanical properties (elongation, adhesion, behaviour towards vapour moisture) and the in vitro availability of miconazole nitrate, used as a pharmaceutical active ingredient in various concentrations. The three polymeric films prepared were translucent or shiny, with the surface of 63.585 cm², 0.20⁻0.30 mm thickness, and content of miconazole nitrate of 3.931 or 15.726 mg·cm². The mechanical resistance and elongation tests demonstrated that the two films based on hydroxyethyl cellulose (HEC) polymer were more elastic than the one prepared with hydroxypropyl methylcellulose (HPMC). The vapour water absorption and vapour water loss capacity of the films revealed that the HPMC film did not dry very well in the process of preparation by the evaporation of the solvent technique, unlike the HEC films that jellified more evenly in water and had higher drying capacity at 40 °C. The in vitro availability of miconazole nitrate from dermal films was evaluated using the Franz diffusion cell method, through a synthetic membrane (Ø 25 mm × 0.45 µm) and acceptor media with pH 7.4 (phosphate buffer and sodium lauryl sulphate 0.045%), resulting a release rate of up to 70%.

Keywords: Franz cell; dermal films; hydroxyethyl cellulose; hydroxypropyl methylcellulose; miconazole nitrate.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Elongation of dermal films as function of tensile strength.
Figure 2
Figure 2
Properties of the film samples used for the in vitro Franz test.
Figure 3
Figure 3
(a) The in vitro availability of miconazole nitrate dermal films expressed by AUC (area under curve); (b) Parameters calculated by linear regression of the released profiles (mg·cm−2 vs. h).

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