Abstract
A newly identified protein from HTLV-III/LAV, the virus implicated as the etiologic agent of the acquired immune deficiency syndrome, was studied. This protein, which has a molecular weight of 27,000 (p27), was shown by amino acid sequencing to have a coding origin 3' to the env gene on the HTLV-III genome. The presence of antibodies to p27 in virus-exposed individuals indicated that this gene is functional in the natural host.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / immunology*
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Acquired Immunodeficiency Syndrome / microbiology
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Amino Acid Sequence
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Animals
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Antibodies, Viral / immunology*
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Antibody Formation
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Antigens, Viral / immunology*
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Deltaretrovirus / genetics
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Deltaretrovirus / immunology*
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Electrophoresis, Polyacrylamide Gel
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Haplorhini / microbiology
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Humans
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Male
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Molecular Weight
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Repetitive Sequences, Nucleic Acid
Substances
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Antibodies, Viral
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Antigens, Viral