Green Therapeutic Biocapsules: Using Plant Cells to Orally Deliver Biopharmaceuticals

Abstract

The use of innovative platforms to produce biopharmaceuticals cheaply and deliver them through noninvasive routes could expand their social benefits. Coverage should increase as a consequence of lower cost and higher patient compliance due to painless administration. For more than two decades of research, oral therapies that rely on genetically engineered plants for the production of biopharmaceuticals have been explored to treat or prevent high-impact diseases. Recent reports on the successful oral delivery of plant-made biopharmaceuticals raise new hopes for the field. Several candidates have shown protection in animal models, and efforts to establish their production on an industrial scale are ongoing. These advances and perspectives for the field are analyzed.

Keywords: cell wall; glucocerebrosidase; immunotherapy; low-cost therapies; oral delivery; plant-based vaccines.