Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018;102(3-4):126-132.
doi: 10.1159/000489853. Epub 2018 Jul 6.

Cyanidin Protects SH-SY5Y Human Neuroblastoma Cells From 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity

Affiliations

Cyanidin Protects SH-SY5Y Human Neuroblastoma Cells From 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity

Jian Chen et al. Pharmacology. .

Abstract

Cyanidin is an anthocyanidin extracted from a variety of fruits and vegetables. Cyanidin showed benefits against diabetes, cancer, and atherosclerosis. However, the potential neuroprotective effects of cyanidin against Parkinson's disease (PD) have not been examined. Indicated concentrations of cyanidin (1, 3, 10, and 30 μmol/L) were incubated together with 0.5 mmol/L 1-methyl-4-phenylpyridinium (MPP+) to human neuroblastoma SH-SY5Y cells. We found cyanidin prevented MPP+-induced cell demise in a concentration-dependent manner. Cyanidin significantly reduced MPP+-induced apoptosis, this is reflected by decreased TdT-mediated dUTP nick-end labeling staining and caspase-3 expressions. Further, MPP+ increased the Bax/Bcl-2 ratio, which was partly reversed by cyanidin. We also found cyanidin attenuated the MPP+-induced mitochondrial oxidative stress as revealed by decreased MitoSOX staining. Taken together, these data for the first time indicated the -neuroprotective effects of cyanidin against MPP+-induced -SH-SY5Y cell death. These findings shed light on the potential implications of cyanidin for PD treatment.

Keywords: 1-methyl-4-phenylpyridinium; Cyanidin; Neuroprotective effects; Parkinson’s disease; SH-SY5Y.

Similar articles

See all similar articles

Cited by 3 articles

MeSH terms

LinkOut - more resources

Feedback