Overview of the Recent Advances in Pathophysiology and Treatment for Autism

CNS Neurol Disord Drug Targets. 2018;17(8):590-594. doi: 10.2174/1871527317666180706141654.


Background & objective: Autism is a developmental disorder that manifests itself in early childhood. Autism is characterized by inability to acquire social skills, repetitive behaviors and failure of speech and nonverbal communication development. Recent studies have shown that genetic mutations occur in majority of individuals with autism. These mutations cause a variety of disorders that ultimately lead to brain disorders. It is noteworthy that all mutations do not follow the same pattern. They encompass various kinds of mutations. Autism needs to be treated during childhood as untreated patients usually do not progress to the later stages of development. In this regard, many studies have been performed and numerous treatments have been proposed to improve the outcome of this disease.

Conclusion: In this review, we have discussed new advancements made in understanding the pathophysiology of autism. Furthermore, we have also discussed new treatments which have been proposed and have successfully translated affected children. Overall, it is concluded that new advances have largely helped these patients.

Keywords: Autism; brain stimulation; gut-brain; immune system; mutation; nutrition..

Publication types

  • Review

MeSH terms

  • Autistic Disorder / epidemiology
  • Autistic Disorder / genetics
  • Autistic Disorder / physiopathology*
  • Autistic Disorder / therapy*
  • Child
  • Deep Brain Stimulation
  • Disease Management*
  • Gastrointestinal Microbiome
  • Humans