PORCUPINE regulates development in response to temperature through alternative splicing

Nat Plants. 2018 Aug;4(8):534-539. doi: 10.1038/s41477-018-0176-z. Epub 2018 Jul 9.


Recent findings suggest that alternative splicing has a critical role in controlling the responses of plants to temperature variations. However, alternative splicing factors in plants are largely uncharacterized. Here we establish the putative splice regulator, PORCUPINE (PCP), as temperature-specific regulator of development in Arabidopsis thaliana. Our findings point to the misregulation of WUSCHEL and CLAVATA3 as the possible cause for the meristem defects affecting the pcp-1 loss-of-function mutants at low temperatures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing*
  • Arabidopsis / anatomy & histology
  • Arabidopsis / genetics*
  • Arabidopsis / growth & development
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism
  • Arabidopsis Proteins / physiology*
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / metabolism
  • RNA Splicing Factors / genetics
  • RNA Splicing Factors / metabolism
  • RNA Splicing Factors / physiology*
  • Temperature*


  • AT2G18740 protein, Arabidopsis
  • AT2G27250 protein, Arabidopsis
  • Arabidopsis Proteins
  • Homeodomain Proteins
  • RNA Splicing Factors
  • WUSCHEL protein, Arabidopsis