Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress

Mable Lam; David A Lawrence; Avi Ashkenazi; Peter Walter

doi:10.1038/s41418-018-0155-y

Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress

Cell Death Differ. 2018 Aug;25(8):1530-1531. doi: 10.1038/s41418-018-0155-y. Epub 2018 Jul 10.

Authors

Mable Lam¹, David A Lawrence², Avi Ashkenazi³, Peter Walter¹

Affiliations

¹ Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, 94158, USA.
² Cancer Immunology, Genentech, Inc., South San Francisco, CA, 94080, USA.
³ Cancer Immunology, Genentech, Inc., South San Francisco, CA, 94080, USA. aa@gene.com.

Abstract

Several studies implicate specific death receptors (DRs) and caspase-8 in mediating apoptosis in response to endoplasmic reticulum (ER) stress; however, a recent paper challenges this conclusion. Here we validate the importance of DR5 and caspase-8 as critical signal conduits for apoptosis activation upon ER stress.

Publication types

Letter

MeSH terms

Apoptosis* / drug effects
Caspase 8 / chemistry
Caspase 8 / genetics
Caspase 8 / metabolism*
Cell Line, Tumor
Endoplasmic Reticulum Stress* / drug effects
Gene Editing
Humans
Poly(ADP-ribose) Polymerases / metabolism
RNA Interference
RNA, Small Interfering / metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand / antagonists & inhibitors
Receptors, TNF-Related Apoptosis-Inducing Ligand / genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand / metabolism*
Thapsigargin / pharmacology

Substances

RNA, Small Interfering
Receptors, TNF-Related Apoptosis-Inducing Ligand
TNFRSF10B protein, human
Thapsigargin
Poly(ADP-ribose) Polymerases
Caspase 8