Abstract
Inspired by cisplatin's deactivation by glutathione (GSH) in cancer, a GSH responsive nanogel loaded with doxorubicin (Dox) was prepared using hyaluronan as a matrix and cisplatin as a crosslinker. The elevated GSH depletes the cisplatin crosslinker in the nanogel, enhances Dox release and boosts cytotoxicity, thus providing a new GSH responsive platform to reverse cisplatin resistance.
MeSH terms
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Cisplatin / chemistry*
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Dose-Response Relationship, Drug
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Doxorubicin / administration & dosage*
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Doxorubicin / chemistry
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Doxorubicin / pharmacology*
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Drug Delivery Systems*
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Gels / chemistry
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Glutathione / chemistry*
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Humans
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Hyaluronic Acid / chemistry
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Nanoparticles / chemistry*
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Oxidation-Reduction
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Spectrometry, Fluorescence
Substances
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Antineoplastic Agents
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Gels
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Doxorubicin
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Hyaluronic Acid
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Glutathione
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Cisplatin