Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 97 (28), e11389

A Meta-Analysis of the Relationship Between Environmental Tobacco Smoke and Lung Cancer Risk of Nonsmoker in China

Affiliations
Review

A Meta-Analysis of the Relationship Between Environmental Tobacco Smoke and Lung Cancer Risk of Nonsmoker in China

Lin Sheng et al. Medicine (Baltimore).

Abstract

Background: To investigate the association between exposure to environmental tobacco smoke (EVT) and the incidence of lung cancer (LC) in nonsmoking adults.

Method: PubMed, Cochrane, Embase, Wanfang, CNKI, and VIP database were searched by the index words to identify the qualified case-control studies, and relevant literature sources were also searched. The latest research was done in June 2017. Odds radio (OR) along with 95% confidence interval (95% CI) were used to analyze the main outcomes.

Result: Twenty RCTs were involved in the meta-analysis with 13,004 adults in the case group and 11,199 adults in the control group. The results indicated that compared with the nonexposure population, the risk of LC incidence was significantly higher in EVT exposure (OR: 1.64, 95% CI: 1.34-2.01), EVT male exposure (OR: 1.62, 95% CI: 1.16-2.28), EVT female exposure (OR: 1.57, 95% CI: 1.43-1.72), EVT exposure at workplace (OR: 1.78, 95% CI: 1.29-2.44), EVT exposure at home (OR: 1.53, 95% CI: 1.01-2.33), and EVT female exposure at home (OR: 1.55, 95% CI: 1.34-1.79). However, there is still no significant difference among the risk of LC incidence in EVT male exposure at workplace (OR: 1.51, 95% CI: 0.74-3.06), EVT female exposure at workplace (OR: 1.23, 95% CI: 0.99-1.53), and EVT male exposure at home (OR: 1.24, 95% CI: 0.68-2.26).

Conclusion: EVT exposure is prospectively associated with a significantly increased risk of LC incidence. More high quality studies are required to address the association between EVT exposure and LC incidence.

Conflict of interest statement

The author(s) have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow diagram of the literature search and selection process.
Figure 2
Figure 2
Forest plot showing the association between EVT exposure and lung cancer incidence.
Figure 3
Figure 3
Forest plot showing the association between EVT exposure and lung cancer incidence of male.
Figure 4
Figure 4
Forest plot showing the association between EVT exposure and lung cancer incidence of female.
Figure 5
Figure 5
Forest plot showing the association between EVT exposure at workplace and lung cancer incidence.
Figure 6
Figure 6
Forest plot showing the association between EVT exposure at workplace and lung cancer incidence of male.
Figure 7
Figure 7
Forest plot showing the association between EVT exposure at workplace and lung cancer incidence of female.
Figure 8
Figure 8
Forest plot showing the association between EVT exposure at home and lung cancer incidence.
Figure 9
Figure 9
Forest plot showing the association between EVT exposure at home and lung cancer incidence of male.
Figure 10
Figure 10
Forest plot showing the association between EVT exposure at home and lung cancer incidence of female.

Similar articles

See all similar articles

References

    1. International Agency for Research on Cancer. GLOBOCAN2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. Available at: URL:http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx.
    1. Liandi L, et al. Analysis the variation tendency of malignant tumor mortality and predict recently. Chin J Oncol 1997;19:3–9.
    1. Jie H, et al. Annual Tumor Registry Review of China in 2012. Beijing: Press of Military Medical Sciences; 2012.
    1. IARC. Lung Cancer Estimated Incidence, Mortality and Prevalence Worldwide in 2012 [EB/OL]. Available at: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx.2012.
    1. Doll R, Peto R, Boreham J, et al. Mortality in relation to smoking: 50 years’ observations on male British doctors. BMJ 2004;328:1519. - PMC - PubMed

Substances

Feedback