Cutaneous Adverse Drug Reactions: How to Identify the Trigger

Abstract

It is estimated that 10% to 15% of medicated patients develop adverse drug reactions (ADR). Despite the high prevalence of ADR, the identification of the trigger drugs remains a medical challenge, mainly in polymedicated patients. Our goal is to update the diagnostic tools to identify enhancer drugs of type B-ADR that compromise the skin and /or mucous membranes, in order to optimize patients' follow-up and improve their quality of life. We develop the review in two stages: I- we review the pathophysiological mechanisms of the ADR; II- we developed the clinical approach for the identification of the triggering drug.

Keywords: Adverse drug reactions; Diagnostic methods; Drug-induced skin disorders; Farmacodermias; Hypersensitivity reactions; Interacción farmacológica de medicamentos con receptores inmunes (CONCEPTO P-I); Métodos de diagnósticos; Pharmacological Interaction of Drugs With Immune Receptors (P-i CONCEPT); Pseudoalergias; Pseudoallergies; Reacciones adversas a medicamentos; Reacciones de hipersensibilidad.