Abstract
A negatively-charged and nucleus-targeted DNA tetrahedron is rationally designed and used as a nanocarrier of positively-charged metal complexes. This tetrahedron speeds up the translocation of metal complexes into the cell nucleus, and inhibits the growth and invasion of glioma cells by triggering vascular mimicry-associated signaling pathways, thus achieving precise glioma treatment.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Cell Line, Tumor
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Cell Nucleus / metabolism
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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DNA / chemistry*
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Drug Carriers / chemistry*
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Drug Stability
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Glioma / drug therapy*
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Humans
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Hydrophobic and Hydrophilic Interactions
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Iridium / chemistry
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Mucin-1 / metabolism
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Nanostructures / chemistry*
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Nucleolin
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Phosphoproteins / metabolism
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RNA-Binding Proteins / metabolism
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Reactive Oxygen Species / metabolism
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Signal Transduction / drug effects
Substances
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Antineoplastic Agents
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Coordination Complexes
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Drug Carriers
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MUC1 protein, human
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Mucin-1
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Phosphoproteins
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RNA-Binding Proteins
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Reactive Oxygen Species
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Iridium
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DNA