Adjunctive laser-stimulated stem-cells therapy to primary reperfusion in acute myocardial infarction in humans: Safety and feasibility study

J Interv Cardiol. 2018 Dec;31(6):711-716. doi: 10.1111/joic.12539. Epub 2018 Jul 12.


Background: Low-level laser therapy (LLLT) has photobiostimulatory effects on stem cells and may offer cardioprotection. This cell-based therapy may compliment primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction (STEMI).

Objective: In this randomized control trial, our primary objective was to determine the safety and feasibility of LLLT application to the bone marrow in patients with STEMI undergoing PPCI.

Methods: We randomly assigned patients undergoing PPCI to LLLT or non-laser therapy (NLT). In the LLLT group, 100 s of laser therapy was applied to the tibia bone prior to PPCI, as well as 24 and 72 h post-PPCI. In the control group, the power source was turned off. The primary outcome was the difference in door-to-balloon (D2B) time, and additional outcomes included differences in circulating cell counts, cardiac enzymes, and left-ventricular ejection fraction (LVEF) at pre-specified intervals post-PPCI.

Results: Twenty-four patients were randomized to LLLT (N = 12) or NLT (N = 12). No adverse effects of the treatment were detected. The D2B time was not significantly different between the groups (41 ± 8 vs 48 ± 1 min; P = 0.73). Creatinine Phosphokinase area under the curve, was lower after LLLT (22 ± 10) compared to NLT (49 ± 12), but this was not statistically significant (P = 0.08). Troponin-T was significantly lower after LLLT (2.7 ± 1.4 ng/mL) in comparison to NLT (5.2 ± 1.8 ng/mL. P < 0.05). At 9 months, LVEF improved in both groups without a significant difference between LLLT (55 ± 9%) and NLT (52 ± 9%; P = 0.90).

Conclusion: LLLT is a safe and feasible adjunctive cell-based therapy to PPCI that may benefit ischemic myocardium.

Keywords: ST segment myocardial infarction; acute myocardial infarction; bone marrow; humans; low level laser therapy; safety.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Blood Cell Count
  • Bone Marrow / radiation effects*
  • Combined Modality Therapy
  • Creatine Kinase / blood
  • Echocardiography
  • Feasibility Studies
  • Female
  • Humans
  • Low-Level Light Therapy / methods*
  • Male
  • Middle Aged
  • Operative Time
  • Percutaneous Coronary Intervention / methods*
  • ST Elevation Myocardial Infarction / therapy*
  • Stem Cells / radiation effects*
  • Stroke Volume
  • Treatment Outcome
  • Troponin T / blood


  • Troponin T
  • Creatine Kinase