Acquired cyclic neutropenia associated with cocaine-induced anti-neutrophil cytoplasmic antibodies binding to human neutrophil elastase

Am J Hematol. 2018 Sep;93(9):E227-E229. doi: 10.1002/ajh.25197. Epub 2018 Aug 31.

Authors

Francesca Schieppati¹, Gina Gregorini², Amber M Hummel³, Mariella D'Adda¹, Erika Borlenghi¹, Cinzia Lamorgese¹, Ulrich Specks³, Giuseppe Rossi¹

Affiliations

¹ Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy.
² Department of Nephrology, ASST Spedali Civili di Brescia, Brescia, Italy.
³ Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

PMID: 29999538
DOI: 10.1002/ajh.25197

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adult
Agranulocytosis / chemically induced
Agranulocytosis / drug therapy
Antibodies, Antineutrophil Cytoplasmic / metabolism*
Cocaine / toxicity*
Female
Granulocyte Colony-Stimulating Factor / therapeutic use
Humans
Immunoglobulins, Intravenous / therapeutic use
Leukocyte Elastase / metabolism*
Male
Middle Aged
Neutropenia / chemically induced*
Protein Binding / drug effects

Substances

Antibodies, Antineutrophil Cytoplasmic
Immunoglobulins, Intravenous
Granulocyte Colony-Stimulating Factor
Leukocyte Elastase
Cocaine

Supplementary concepts

Cyclic neutropenia