In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.


Limited information indicates that maternal pyrazinamide therapy produces potentially substantial levels in milk. Exclusively breastfed infants should be monitored for rare cases of jaundice, hepatitis and arthralgia if this drug is used during lactation.[1] The amount of pyrazinamide in milk is probably insufficient to treat tuberculosis in the breastfed infant, but if both the mother and breastfed infant are receiving the drug, infant serum levels could be monitored to assess for excessive infant serum concentrations. The Centers for Disease Control and Prevention and other professional organizations state that breastfeeding should not be discouraged in women taking pyrazinamide.[2]

Publication types

  • Review