Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle

Exerc Sport Sci Rev. 2018 Oct;46(4):254-261. doi: 10.1249/JES.0000000000000167.


Dietary nitrate, a source of nitric oxide (NO), improves the contractile properties of human muscle. We present the hypothesis that this is due to nitrosylation of the ryanodine receptor and increased NO signaling via the soluble guanyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway, which together increase the free intracellular Ca concentration along with the Ca sensitivity of the myofilaments themselves.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Calcium / physiology
  • Cyclic GMP / physiology
  • Cyclic GMP-Dependent Protein Kinases / physiology
  • Diet*
  • Humans
  • Muscle Contraction*
  • Muscle, Skeletal / physiology*
  • Nitrates / physiology*
  • Nitric Oxide / physiology
  • Ryanodine Receptor Calcium Release Channel / physiology
  • Signal Transduction


  • Nitrates
  • Ryanodine Receptor Calcium Release Channel
  • Nitric Oxide
  • Cyclic GMP-Dependent Protein Kinases
  • Cyclic GMP
  • Calcium