Dendritic Tau in Alzheimer's Disease

Neuron. 2018 Jul 11;99(1):13-27. doi: 10.1016/j.neuron.2018.06.003.


The microtubule-associated protein tau and amyloid-β (Aβ) are key players in Alzheimer's disease (AD). Aβ and tau are linked in a molecular pathway at the post-synapse with tau-dependent synaptic dysfunction being a major pathomechanism in AD. Recent work on site-specific modification of dendritic and more specifically post-synaptic tau has revealed new endogenous functions of tau that limits synaptic Aβ toxicity. Thus, molecular studies opened a new perspective on tau, placing it at the center of neurotoxic and neuroprotective signaling at the post-synapse. Here, we review recent advances on tau in the dendritic compartments, with implications for understanding and treatment of AD and related neurological conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Amyloid beta-Peptides / metabolism*
  • Dendrites / metabolism*
  • Humans
  • Neurofibrillary Tangles
  • Neurons / metabolism
  • Plaque, Amyloid / metabolism
  • Synapses / metabolism*
  • tau Proteins / metabolism*


  • Amyloid beta-Peptides
  • tau Proteins