Intravitreal amphotericin B treatment of Candida endophthamitis

Arch Ophthalmol. 1977 Jan;95(1):89-93. doi: 10.1001/archopht.1977.04450010089008.


A 43-year-old heroin addict with Candida albicans endophthalmitis was treated with a single 5-mug intravitreal injection of amphotericin B. The diagnosis was confirmed by smears and cultures of a vitrous aspiration. The patient's accidental death seven weeks after treatment enabled us to obtain histopathologic evidence that the infection had been cured and that the amphotericin B had had no toxic effect on the retina. Intravitral amphotericin B should be considered an important mode of treatment of Candida endophthalmitis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amphotericin B / therapeutic use*
  • Candidiasis / complications
  • Candidiasis / drug therapy*
  • Candidiasis / pathology
  • Endophthalmitis / drug therapy*
  • Endophthalmitis / microbiology
  • Endophthalmitis / pathology
  • Fluorescein Angiography
  • Humans
  • Male
  • Phenmetrazine
  • Substance-Related Disorders / complications
  • Visual Acuity


  • Amphotericin B
  • Phenmetrazine