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Review
. 2018 Sep;39(9):734-747.
doi: 10.1016/j.it.2018.06.003. Epub 2018 Jul 11.

Peripheral Tissue Chemokines: Homeostatic Control of Immune Surveillance T Cells

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Review

Peripheral Tissue Chemokines: Homeostatic Control of Immune Surveillance T Cells

Michelle L McCully et al. Trends Immunol. .

Abstract

Cellular immunity is governed by a complex network of migratory cues that enable appropriate immune cell responses in a timely and spatially controlled fashion. This review focuses on the chemokines and their receptors regulating the steady-state localisation of immune cells within healthy peripheral tissues. Steady-state immune cell traffic is not well understood but is thought to involve constitutive (homeostatic) chemokines. The recent discovery of tissue-resident memory T cells (TRM cells) illustrates our need for understanding how chemokines control immune cell mobilisation and/or retention. These studies will be critical to unravel novel pathways for preserving tissue function (aging) and preventing tissue disease (vaccination).

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