Changes of the echocardiographic parameters in chronic heart failure patients with Ile337val, Glu23lys, and Ser1369ala polymorphisms of genes encoding the ATP-sensitive potassium channels subunits in the Ukrainian population

doi:10.1111/ahg.12250

. 2018 Sep;82(5):272-279.

doi: 10.1111/ahg.12250. Epub 2018 Jul 13.

Changes of the echocardiographic parameters in chronic heart failure patients with Ile337val, Glu23lys, and Ser1369ala polymorphisms of genes encoding the ATP-sensitive potassium channels subunits in the Ukrainian population

R B Strutynskyi¹, L G Voronkov², V S Nagibin¹, I D Mazur², D Stroy¹, V E Dosenko¹

Affiliations

¹ Department of General and Molecular Pathophysiology, Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
² Department of Heart Failure, State Institution «National scientific center «M.D. Strazhesko Institute of Cardiology» National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.

PMID: 30003549
DOI: 10.1111/ahg.12250

Changes of the echocardiographic parameters in chronic heart failure patients with Ile337val, Glu23lys, and Ser1369ala polymorphisms of genes encoding the ATP-sensitive potassium channels subunits in the Ukrainian population

R B Strutynskyi et al. Ann Hum Genet. 2018 Sep.

. 2018 Sep;82(5):272-279.

doi: 10.1111/ahg.12250. Epub 2018 Jul 13.

Authors

R B Strutynskyi¹, L G Voronkov², V S Nagibin¹, I D Mazur², D Stroy¹, V E Dosenko¹

Affiliations

¹ Department of General and Molecular Pathophysiology, Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
² Department of Heart Failure, State Institution «National scientific center «M.D. Strazhesko Institute of Cardiology» National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.

PMID: 30003549
DOI: 10.1111/ahg.12250

Abstract

Different allelic variants of genes that encode ATP-sensitive potassium (K_ATP ) channels' subunits may contribute to the development of heart failure. The purpose of the work to investigate SNPs in genes that encode K_ATP channels in relation to echocardiographic parameters in chronic heart failure (CHF) patients. Ninety-nine people with CHF of ischemic origin with left ventricular systolic dysfunction were examined. The control group is represented by 108 clinically healthy subjects. KCNJ11 polymorphisms Ile337Val and Glu23Lys, and ABCC8 polymorphism Ser1369Ala were genotyped using polymerase chain reaction. In CHF patients, the frequency of the Ile337Val genotype was: Ile/Ile, 40.4%; Ile/Val, 45.5%; and Val/Val, 14.1%. The patients with the Val/Val genotype had left ventricular (LV) mass that was 334.15 g, which was 27.3% (P < 0.05) lower versus Ile/Val patients (425.48 g). The index of this parameter was also significantly lower (28.4%, P < 0.05). In CHF patients, the frequency of Glu23Lys and Ser1369Ala was: Glu/Glu and Ser/Ser, 43.4%; heterozygote, 44.4%; Lys/Lys and Ala/Ala, 12.2%. The patients with the Lys/Lys and Ala/Ala genotypes had a significantly lower LV mass index and LV end-diastolic volume (22.9% and 26.8%, P < 0.05) versus heterozygotes. Thus, the greatest LV mass and LV end-diastolic volume values are associated with heterozygotes, while the smallest are associated with minor homozygotes.

Keywords: Chronic heart failure; echocardiography; rs5215; rs5219; rs757110.

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References

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1. Chutkow, W. A., Simon, M. C., Le Beau, M. M., & Burant, C. F. (1996). Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels. Diabetes, 45, 1439-1445.
1. Horinaka, S., Kobayashi, N., Yabe, A., Asakawa, H., Yagi, H., Mori, Y., ... Matsuoka, H. (2004). Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction. Cardiovascular Drugs and Therapy, 18, 13-22. https://doi.org/10.1023/B:CARD.0000025751.82774.a9
1. Hu, X., Xu, X., Huang, Y., Fassett, J., Flagg, T. P., Zhang, Y., ... Chen, Y. (2008). Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload. Circulation Research, 103, 1009-1017. https://doi.org/10.1161/CIRCRESAHA.107.170795
1. Kane, G. C., Behfar, A., Dyer, R. B., O'Cochlain, D. F., Liu, X. K., Hodgson, D. M., ... Terzic, A. (2006). KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure in hypertension. Human Molecular Genetics, 15, 2285-2297. https://doi.org/10.1093/hmg/ddl154

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[1] Bienengraeber, M., Olson, T. M., Selivanov, V. A., Kathmann, E. C., O'Cochlain, F., Gao, F., ... Terzic, A. (2004). ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nature Genetics, 36, 382-387. https://doi.org/10.1038/ng1329

[2] Bienengraeber, M., Olson, T. M., Selivanov, V. A., Kathmann, E. C., O'Cochlain, F., Gao, F., ... Terzic, A. (2004). ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nature Genetics, 36, 382-387. https://doi.org/10.1038/ng1329

[3] Chutkow, W. A., Simon, M. C., Le Beau, M. M., & Burant, C. F. (1996). Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels. Diabetes, 45, 1439-1445.

[4] Chutkow, W. A., Simon, M. C., Le Beau, M. M., & Burant, C. F. (1996). Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels. Diabetes, 45, 1439-1445.

[5] Horinaka, S., Kobayashi, N., Yabe, A., Asakawa, H., Yagi, H., Mori, Y., ... Matsuoka, H. (2004). Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction. Cardiovascular Drugs and Therapy, 18, 13-22. https://doi.org/10.1023/B:CARD.0000025751.82774.a9

[6] Horinaka, S., Kobayashi, N., Yabe, A., Asakawa, H., Yagi, H., Mori, Y., ... Matsuoka, H. (2004). Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction. Cardiovascular Drugs and Therapy, 18, 13-22. https://doi.org/10.1023/B:CARD.0000025751.82774.a9

[7] Hu, X., Xu, X., Huang, Y., Fassett, J., Flagg, T. P., Zhang, Y., ... Chen, Y. (2008). Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload. Circulation Research, 103, 1009-1017. https://doi.org/10.1161/CIRCRESAHA.107.170795

[8] Hu, X., Xu, X., Huang, Y., Fassett, J., Flagg, T. P., Zhang, Y., ... Chen, Y. (2008). Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload. Circulation Research, 103, 1009-1017. https://doi.org/10.1161/CIRCRESAHA.107.170795

[9] Kane, G. C., Behfar, A., Dyer, R. B., O'Cochlain, D. F., Liu, X. K., Hodgson, D. M., ... Terzic, A. (2006). KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure in hypertension. Human Molecular Genetics, 15, 2285-2297. https://doi.org/10.1093/hmg/ddl154

[10] Kane, G. C., Behfar, A., Dyer, R. B., O'Cochlain, D. F., Liu, X. K., Hodgson, D. M., ... Terzic, A. (2006). KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure in hypertension. Human Molecular Genetics, 15, 2285-2297. https://doi.org/10.1093/hmg/ddl154

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Changes of the echocardiographic parameters in chronic heart failure patients with Ile337val, Glu23lys, and Ser1369ala polymorphisms of genes encoding the ATP-sensitive potassium channels subunits in the Ukrainian population

Affiliations

Changes of the echocardiographic parameters in chronic heart failure patients with Ile337val, Glu23lys, and Ser1369ala polymorphisms of genes encoding the ATP-sensitive potassium channels subunits in the Ukrainian population

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