The effects of therapeutic irradiation on lymphocytes and immunity

Cancer. 1977 Feb;39(2 Suppl):737-43. doi: 10.1002/1097-0142(197702)39:2+<737::aid-cncr2820390708>3.0.co;2-m.

Abstract

The lymphocytotoxic effect of therapeutic irradiation may lead to immune depression. The significance of such effects is yet to be determined in many malignancies, especially in light of the persistant immune depression in many "cured" patients. The present review examines the effects of age, type of cancer, and stage of disease as well as the results of immune parameters following radiation therapy. Factors to be considered in both the analysis of present day data and in future studies are also reviewed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age Factors
  • B-Lymphocytes / immunology
  • B-Lymphocytes / radiation effects
  • Female
  • Humans
  • Immunity / radiation effects*
  • Immunotherapy
  • Leukocyte Count
  • Lymphocyte Activation
  • Lymphocytes / radiation effects*
  • Lymphopenia / etiology
  • Macrophages / immunology
  • Male
  • Middle Aged
  • Neoplasms / immunology
  • Neoplasms / pathology
  • Neoplasms / radiotherapy*
  • Neoplasms / therapy
  • Plasma Cells / immunology
  • Radiation Tolerance
  • T-Lymphocytes / immunology
  • T-Lymphocytes / radiation effects