Bone mineral density and serum osteocalcin levels in patients with gout

Acta Clin Belg. 2019 Aug;74(4):252-257. doi: 10.1080/17843286.2018.1495389. Epub 2018 Jul 13.


Objective: The objective of the study is to evaluate the relation of gout with osteoporosis and serum osteocalcin (OC) levels. Material and methods: Seventy-five patients diagnosed with gout and 55 controls were included in the study. Comorbid conditions and drugs associated with osteoporosis were excluded. The T and Z scores from lumbar spine (L2-L4) and femur (neck, ward, trochanter, total) were determined by dual-energy X-ray absorptiometry (DXA). OC levels were measured by enzyme-linked immunosorbent assay. Results: Osteoporosis according to T scores of lumbar vertebrae L2-L4 was found to be significantly higher in patients with gout compared to the control group (p = 0.02). Lumbar spine T-score was -1.6 in gout group and -1.0 in controls. OC level was 7.9 ng/mL in the gout group and 18.9 ng/mL in the control group. There was a significant difference (p < 0.001). In addition, mean OC level was 12.4 ± 6.9 ng/mL in the patients diagnosed with osteoporosis and 17.2 ± 10.6 ng/mL in the patients that were classified as normal and a significant difference was established between the two groups (p = 0.03). A significant negative correlation was found between OC level and body mass index, age, and age at first attack. Similarly, femoral T-score established a negative correlation with parathyroid hormone, age, age at first attack, and allopurinol dose. Conclusion: Serum OC level can be a useful marker in the assessment of bone turnover and clinicians should keep osteoporosis in mind in gout patients.

Keywords: Gout; Osteocalcin; Osteoporosis.

MeSH terms

  • Absorptiometry, Photon / methods
  • Age Factors
  • Allopurinol / therapeutic use*
  • Body Mass Index
  • Bone Remodeling*
  • Correlation of Data
  • Female
  • Femur / diagnostic imaging
  • Gout Suppressants / therapeutic use
  • Gout* / blood
  • Gout* / diagnosis
  • Gout* / drug therapy
  • Gout* / epidemiology
  • Humans
  • Lumbar Vertebrae / diagnostic imaging
  • Male
  • Middle Aged
  • Osteocalcin / blood*
  • Osteoporosis* / blood
  • Osteoporosis* / diagnosis
  • Osteoporosis* / epidemiology
  • Turkey / epidemiology


  • Gout Suppressants
  • Osteocalcin
  • Allopurinol