Clinical Characteristics of Lower Extremity Surgical Site Infections in Dermatologic Surgery Based Upon 24-Month Retrospective Review

J Drugs Dermatol. 2018 Jul 1;17(7):766-771.

Abstract

Dermatologic surgery performed on the lower extremities has an increased risk for surgical site infections (SSI). Our objective was to evaluate the clinical characteristics associated with SSI following Mohs micrographic surgery (MMS) and wide local excisions (WLE) performed below the knee. We performed a single-center retrospective chart review of patients (n=271) that underwent these procedures. Within 14 days of the lower extremity procedure, four of 175 MMS patients (2.3%) developed SSI compared to eight of 96 WLE patients (8.3%; P=0.029). Subcuticular sutures and vertical mattress sutures as a group were associated with reduced 30-day infection rate when compared to other suture methods (P=0.006). Comparison of patients on prophylactic antibiotics to control patients without antibiotics did not reveal a statistically significant difference in infection rate. MMS infection rates trended lower as compared to WLE in the 14-day post-operative window. Doxycycline prophylaxis did not produce a statistically significantly lower rate of SSI, though results approached significance. A prospective study may be warranted to further compare cephalexin and doxycycline for dermatologic surgery below the knee. Subcuticular or vertical mattress sutures may be preferred when closing wounds due to their association with reduced infection rate. J Drugs Dermatol. 2018;17(7):766-771.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antibiotic Prophylaxis / methods*
  • Cephalexin / therapeutic use
  • Dermatologic Surgical Procedures / adverse effects*
  • Dermatologic Surgical Procedures / methods
  • Doxycycline / therapeutic use
  • Emollients / pharmacology
  • Emollients / therapeutic use*
  • Epidermis / drug effects
  • Epidermis / physiopathology
  • Female
  • Foot
  • Humans
  • Incidence
  • Leg
  • Male
  • Middle Aged
  • Retrospective Studies
  • Skin Cream / pharmacology
  • Skin Cream / therapeutic use*
  • Surgical Wound Infection / drug therapy*
  • Surgical Wound Infection / epidemiology
  • Surgical Wound Infection / etiology
  • Surgical Wound Infection / prevention & control
  • Suture Techniques / adverse effects
  • Treatment Outcome
  • Water Loss, Insensible / drug effects
  • Water Loss, Insensible / physiology

Substances

  • Emollients
  • Doxycycline
  • Cephalexin