An efficient synthesis of trace amine-associated receptor agonist [1-14 C]tyramine

Crist N Filer; Demetri Orphanos

doi:10.1002/jlcr.3671

An efficient synthesis of trace amine-associated receptor agonist [1-¹⁴ C]tyramine

J Labelled Comp Radiopharm. 2019 Jan;62(1):24-27. doi: 10.1002/jlcr.3671. Epub 2018 Jul 31.

Authors

Crist N Filer¹, Demetri Orphanos¹

Affiliation

¹ Custom Synthesis, PerkinElmer Health Sciences Inc., Waltham, MA, USA.

PMID: 30007086
DOI: 10.1002/jlcr.3671

Abstract

The 2-step synthesis of [1-¹⁴ C]tyramine hydrochloride is described with the product being characterized by TLC, HPLC, and UV spectroscopy. Several methods are provided to purify [1-¹⁴ C]tyramine hydrochloride, and its storage and stability are also discussed.

Keywords: carbon-14; trace amine; tyramine.

MeSH terms

Carbon Radioisotopes / chemistry*
Radiopharmaceuticals / chemical synthesis*
Receptors, G-Protein-Coupled / agonists
Tyramine / analogs & derivatives*
Tyramine / pharmacology

Substances

Carbon Radioisotopes
Radiopharmaceuticals
Receptors, G-Protein-Coupled
Tyramine