Bench to bedside: Current advances in regenerative medicine

Curr Opin Cell Biol. 2018 Dec;55:59-66. doi: 10.1016/j.ceb.2018.05.006. Epub 2018 Jul 11.

Abstract

Regenerative medicine is a diverse and rapidly evolving field, employing core expertise from biologists, engineers, and clinicians. Recently the field has made significant progress towards regenerating or replacing tissues lost to age, disease or injury. Current strategies include transplantation of adult or pluripotent stem cells to replace tissue or support tissue healing. Promising approaches for the future of regenerative medicine include stimulating endogenous stem cells for in situ repair, transplantation of organoids to repair minor tissue injury, and the use of interspecies chimerism to produce functional metabolic organs for transplantation. In our review we focus on these emerging strategies, paying particular attention to their current and prospective translational impacts and challenges.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Humans
  • Organoids / metabolism
  • Regeneration
  • Regenerative Medicine / trends*
  • Stem Cell Transplantation
  • Tissue Engineering
  • Translational Medical Research*