The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis

Cell. 2018 Jul 12;174(2):251-253. doi: 10.1016/j.cell.2018.06.037.


The intestinal response to helminth infection is mediated by a recently established type 2 immune circuit that consists of intestinal tuft cells and type 2 innate lymphoid cells (ILC2s). Schneider et al. have discovered that tuft cells sense succinate fermented by Tritrichomonas via GPR91 to drive the IL-25-ILC2-IL-13-dependent immune circuit and intestinal remodeling.

Publication types

  • Comment

MeSH terms

  • Homeostasis / immunology
  • Immunity, Innate / immunology*
  • Interleukin-13 / immunology
  • Intestine, Small / immunology*
  • Intestines
  • Lymphocytes / immunology


  • Interleukin-13