Abstract
The effect of flunitrazepam and DMCM was examined on the kinetics of [35S]t-butylbicyclophosphorothionate (TBPS) binding. The enhancing effect of flunitrazepam and the decreasing effect of DMCM on TBPS binding was due to non-equilibrium conditions. The anticonvulsant benzodiazepine increased both the association and dissociation rate constants. The convulsant beta-carboline had the opposite effect. Benzodiazepine receptor ligands might affect the convulsant TBPS sites parallel with opening/closing of the chloride ionophores.
MeSH terms
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Animals
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Anticonvulsants / pharmacology*
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Benzodiazepines / pharmacology*
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Bridged Bicyclo Compounds / metabolism*
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Bridged Bicyclo Compounds, Heterocyclic*
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Bridged-Ring Compounds / metabolism*
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Carbolines / pharmacology*
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Chlorides / metabolism*
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Convulsants / pharmacology*
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Flunitrazepam / pharmacology
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In Vitro Techniques
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Ionophores / metabolism*
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Male
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Rats
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Rats, Inbred Strains
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Receptors, GABA-A / drug effects
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Synaptic Membranes / metabolism
Substances
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Anticonvulsants
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Bridged Bicyclo Compounds
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Bridged Bicyclo Compounds, Heterocyclic
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Bridged-Ring Compounds
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Carbolines
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Chlorides
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Convulsants
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Ionophores
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Receptors, GABA-A
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Benzodiazepines
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methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate
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Flunitrazepam
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tert-butylbicyclophosphorothionate