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. 1985 Nov 19;117(3):373-5.
doi: 10.1016/0014-2999(85)90012-3.

Modulation of Cholinergic Neurotransmission in Canine Airways by Thromboxane Mimetic U46619

Modulation of Cholinergic Neurotransmission in Canine Airways by Thromboxane Mimetic U46619

K F Chung et al. Eur J Pharmacol. .

Abstract

We studied the effect of a thromboxane A2-mimetic, U46619, on the contractile responses of canine bronchial smooth muscle to cholinergic stimulation in vitro. U46619 (3 X 10(-10) M), at a concentration that did not cause contraction, enhanced the effect of electrical field stimulation at all frequencies; histamine (10(-7) M) and prostaglandin F2 alpha (10(-7) M) did not. U46619 (3 X 10(-10) M) did not affect methacholine-induced contractions. U46619 may therefore increase the prejunctional release of acetylcholine.

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