Physiological and molecular correlates of age-related changes in the human beta-adrenergic receptor system

Fed Proc. 1986 Jan;45(1):48-50.


Aging decreases hormone responsiveness in several receptor systems. In this article I consider both physiological and biochemical studies supporting the hypothesis that beta-adrenergic receptor responsiveness is reduced with aging in humans. Reduced chronotropic and vasodilator responses to the beta-receptor agonists isoproterenol and metaproterenol have been demonstrated. In human leukocytes a reduction in adenylate cyclase (EC activity occurs with aging. More recently it has been suggested that this reduction in beta-adrenergic responsiveness with aging may be caused by an uncoupling of the beta receptor from the catalytic component.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging*
  • Cyclic AMP / biosynthesis
  • Heart / physiopathology
  • Humans
  • Leukocytes / physiology
  • Receptors, Adrenergic, beta / metabolism
  • Receptors, Adrenergic, beta / physiology*


  • Receptors, Adrenergic, beta
  • Cyclic AMP