Intervirology. 1985;24(4):183-92. doi: 10.1159/000149642.


The family Flaviviridae comprises the genus Flavivirus, which contains 65 related species and two possible members. They are small, enveloped RNA viruses (diameter 45 nm) with peplomers comprising a single glycoprotein E. Other structural proteins are designated C (core) and M (membrane-like). The single strand of RNA is infectious and has a molecular weight of about 4 X 10(6) and an m7G 'cap' at the 5' end but no poly(A) tract at the 3' end; it functions as the sole messenger. The gene sequence commences 5'-C-M-E.... The replication strategy and the mode of morphogenesis are distinct from those of the Togaviridae which are slightly larger and morphologically similar in some respects. Flaviviruses infect a wide range of vertebrates, and many are transmitted by arthropods.

Publication types

  • Review

MeSH terms

  • Alphavirus / classification
  • Animals
  • Endoplasmic Reticulum / microbiology
  • Endoplasmic Reticulum / ultrastructure
  • Flavivirus / classification*
  • Flavivirus / genetics
  • Flavivirus / physiology
  • Flavivirus / ultrastructure
  • Genes, Viral
  • Morphogenesis
  • RNA, Viral / biosynthesis
  • RNA, Viral / genetics
  • Viral Core Proteins / analysis
  • Viral Envelope Proteins / analysis
  • Viral Matrix Proteins
  • Viral Proteins / analysis
  • Viral Proteins / biosynthesis
  • Virus Replication


  • RNA, Viral
  • Viral Core Proteins
  • Viral Envelope Proteins
  • Viral Matrix Proteins
  • Viral Proteins