Adaptive optics ophthalmoscopy: Application to age-related macular degeneration and vascular diseases

Prog Retin Eye Res. 2018 Sep;66:1-16. doi: 10.1016/j.preteyeres.2018.07.001. Epub 2018 Jul 17.


Adaptive optics (AO)-enhanced en face retinal imaging, termed here AO ophthalmoscopy (AOO) has reached a level of robustness which fuels its increasing use in research and clinical centers. Here we will review the contribution of clinical AOO to the understanding and monitoring of 1) age-related macular degeneration and 2) vascular diseases. The main contributions of AOO to the phenotyping of AMD are a better identification of drusen, a better delineation of the limits of atrophy, and the identification of novel features such as punctate hyperreflectivity and mobile melanin-containing clumps. Characterization of progression of atrophy is facilitated by time-lapse imaging. In vessels, AOO enables the observation and measurement of parietal structures and the observation of microscopic pathological features such as small hemorrhages and inflammatory cell accumulations.

Trial registration: NCT01546181.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Atrophy
  • Humans
  • Macular Degeneration / diagnostic imaging*
  • Ophthalmoscopy / methods*
  • Optics and Photonics / methods*
  • Peripheral Vascular Diseases / diagnostic imaging*
  • Retinal Vessels / diagnostic imaging

Associated data