Bone Marrow-Derived and Adipose-Derived Mesenchymal Stem Cell Therapy in Primary Knee Osteoarthritis: A Narrative Review

PM R. 2019 Feb;11(2):177-191. doi: 10.1016/j.pmrj.2018.06.019. Epub 2019 Jan 16.


Regenerative medicine in the context of musculoskeletal injury is a broad term that offers potential therapeutic solutions to restore or repair damaged tissue. The current focus in recent literature and clinical practice has been on cell based therapy. In particular, much attention has been centered on autologous bone marrow concentrate and adipose-derived mesenchymal stem cells (MSCs) for cartilage and tendon disorders. This article provides an overview of MSC-derived therapy and offers a comprehensive review of adipose- and bone marrow-derived MSC therapy in primary knee osteoarthritis. LEVEL OF EVIDENCE: IV.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / cytology*
  • Bone Marrow Cells / cytology*
  • Bone Marrow Transplantation / methods*
  • Humans
  • Mesenchymal Stem Cell Transplantation / methods*
  • Osteoarthritis, Knee / therapy*
  • Regenerative Medicine / methods*