Alternative and Adjunctive Treatments for Dupuytren Disease

Abstract

Clinicians struggle with limited efficacy and durability of standard treatments when treating patients with Dupuytren disease diathesis. Alternative treatments such as low-dose radiation therapy in early phase of disease, supplemental pharmacotherapy with anti-inflammatory and/or anti-mitotic drugs, as well as other pharmacologic targets, and more aggressive surgery such as dermofasciectomy all have been reported with variable success or with serious side effects that hamper their standard use. This article gives an overview of the available literature.

Keywords: Dermofasciectomy; Dupuytren; Firebreak skin graft; Pharmacotherapy; Radiotherapy.