Tricaprin Rescues Myocardial Abnormality in a Mouse Model of Triglyceride Deposit Cardiomyovasculopathy

J Oleo Sci. 2018 Aug 1;67(8):983-989. doi: 10.5650/jos.ess18037. Epub 2018 Jul 17.


Triglyceride deposit cardiomyovasculopathy (TGCV) is an intractable cardiovascular disease for which a specific treatment is urgently required. In TGCV, adipose triglyceride lipase (ATGL) deficiency results in the abnormal intracellular metabolism of long-chain fatty acid (LCFA) which leads to TG deposition. Medium-chain triglycerides have been used as an important functional food for various human diseases. To address the potential activities of tricaprin, a medium-chain triglyceride, on cardiac dysfunctions of TGCV, we examined the effects of tricaprin diet on Atgl knock out (KO) mice, an animal model for TGCV. Cardiac imaging tests showed that the tricaprin diet reduced TG accumulation, resulting from improvement of LCFA metabolism, and improved left ventricular function in Atgl KO mice compared to that in mice fed the control diet. In conclusion, tricaprin improved myocardial abnormality in the TGCV model, thus, it may be useful for the treatment of patients with TGCV.

Keywords: adipose triglyceride lipase; capric acid; iodine-123-β-methyl iodophenyl-pentadecanoic acid; medium-chain triglyceride; tricaprin; triglyceride deposit cardiomyovasculopathy.

MeSH terms

  • Animals
  • Cardiovascular Diseases / diagnostic imaging
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / metabolism*
  • Disease Models, Animal
  • Fatty Acids / metabolism
  • Heart / diagnostic imaging
  • Humans
  • Lipase / deficiency*
  • Mice, Knockout
  • Myocardium / metabolism*
  • Triglycerides / administration & dosage
  • Triglycerides / metabolism*


  • Fatty Acids
  • Triglycerides
  • Lipase
  • PNPLA2 protein, mouse
  • tricaprin