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Randomized Controlled Trial
. 2018 Aug 29;64(2):73-81.
doi: 10.5387/fms.2018-07. Epub 2018 Jul 14.

Comparisons Between the Efficacy of Limaprost Alfadex and Pregabalin in Cervical Spondylotic Radiculopathy : Design of a Randomized Controlled Trial

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Free PMC article
Randomized Controlled Trial

Comparisons Between the Efficacy of Limaprost Alfadex and Pregabalin in Cervical Spondylotic Radiculopathy : Design of a Randomized Controlled Trial

Akira Onda et al. Fukushima J Med Sci. .
Free PMC article

Abstract

Background: Cervical spondylotic radiculopathy (CSR) is a relatively common neurological disease caused by the mechanical compression of nerve roots. Limaprost, a prostaglandin E1 derivative, functions as a vasodilator and has been used in the treatment of lumbar spinal stenosis in Japan. However, the effects of limaprost in cervical radiculopathy remain unclear. Our aim was to compare the efficacy of limaprost with that of pregabalin, which is widely used for the treatment of neuropathic pain.

Methods: In this randomized trial, patients with CSR received either limaprost or pregabalin orally for 8 weeks, along with nonsteroidal anti-inflammatory drugs. The primary outcomes were assessed using a numerical rating scale of pain and numbness, both at rest and during movement. Secondary outcomes were assessed using Short Form-36, provocation tests, painDETECT questionnaire, and subjective global assessment. The obtained data were evaluated according to the per-protocol analysis principle.

Results: A total of 46 patients were enrolled in this study, and 35 were available for analysis. A greater reduction in pain score was observed in neck pain during movement, and scapular and arm pain both at rest and during movement in the pregabalin-treated group up to 4 weeks. In the limaprost-treated group, numbness of the arm during movement showed a marked alleviation compared to the pregabalin-treated group at 8 weeks. There were no apparent differences between the two groups in terms of the secondary outcomes.

Conclusions: Although pregabalin provided an earlier pain relief than limaprost, limaprost was superior to pregabalin in treating arm numbness. Limaprost might be one of the effective therapeutic options for CSR in primary care settings.

Keywords: cervical radiculopathy; limaprost; prostaglandin E1 and pregabalin.

Figures

Fig. 1.
Fig. 1.
Study flow diagram Of 46 eligible participants, six were lost to follow-up, three needed additional analgesia, and two discontinued because of adverse effects. The remaining 35 participants completed this study. NSAIDs, nonsteroidal anti-inflammatory drugs; L + N, limaprost plus NSAIDs; P + N, pregabalin plus NSAIDs

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