Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory

Nat Commun. 2018 Jul 16;9(1):2735. doi: 10.1038/s41467-018-05131-6.

Abstract

The hippocampus is essential for representing spatiotemporal context and establishing its association with the sensory details of daily life to form episodic memories. The olfactory cortex in particular shares exclusive anatomical connections with the hippocampus as a result of their common evolutionary history. Here we selectively inhibit hippocampal projections to the anterior olfactory nucleus (AON) during behavioural tests of contextually cued odour recall. We find that spatial odour memory and temporal odour memory are independently impaired following inhibition of distinct, topographically organized hippocampal-AON pathways. Our results not only reveal a longstanding unknown function for the AON but offer new mechanistic insights regarding the representation of odours in episodic memory.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / pharmacology
  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Clozapine / analogs & derivatives
  • Clozapine / pharmacology
  • Cues
  • Electrodes, Implanted
  • Genes, Reporter
  • Hippocampus / anatomy & histology
  • Hippocampus / drug effects
  • Hippocampus / physiology*
  • Limonene / pharmacology
  • Luminescent Proteins / genetics
  • Luminescent Proteins / metabolism
  • Male
  • Memory, Episodic*
  • Mental Recall / physiology
  • Mice
  • Mice, Inbred C57BL
  • Odorants / analysis*
  • Olfactory Bulb / anatomy & histology
  • Olfactory Bulb / drug effects
  • Olfactory Bulb / physiology
  • Olfactory Cortex / anatomy & histology
  • Olfactory Cortex / drug effects
  • Olfactory Cortex / physiology*
  • Olfactory Pathways / anatomy & histology
  • Olfactory Pathways / drug effects
  • Olfactory Pathways / physiology
  • Optogenetics
  • Pentanols / pharmacology
  • Space Perception / physiology*
  • Stereotaxic Techniques
  • Temporal Lobe / anatomy & histology
  • Temporal Lobe / physiology
  • Time Perception / physiology*

Substances

  • Alkanes
  • Bacterial Proteins
  • Luminescent Proteins
  • Pentanols
  • red fluorescent protein
  • yellow fluorescent protein, Bacteria
  • Limonene
  • Clozapine
  • n-pentanol
  • clozapine N-oxide
  • nonane
  • isoamyl acetate