Planar cell polarity in organ formation

Deborah J Henderson; David A Long; Charlotte H Dean

doi:10.1016/j.ceb.2018.06.011

Planar cell polarity in organ formation

Curr Opin Cell Biol. 2018 Dec:55:96-103. doi: 10.1016/j.ceb.2018.06.011. Epub 2018 Jul 14.

Authors

Deborah J Henderson¹, David A Long², Charlotte H Dean³

Affiliations

¹ Cardiovascular Research Centre, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
² Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK.
³ Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College, London, UK. Electronic address: c.dean@imperial.ac.uk.

PMID: 30015152
DOI: 10.1016/j.ceb.2018.06.011

Abstract

The planar cell polarity (PCP) pathway controls a variety of morphological events across many species. During embryonic development, the PCP pathway regulates coordinated behaviour of groups of cells to direct morphogenetic processes such as convergent extension and collective cell migration. In this review we discuss the increasingly prominent role of the PCP pathway in organogenesis, focusing on the lungs, kidneys and heart. We also highlight emerging evidence that PCP gene mutations are associated with adult diseases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Movement
Cell Polarity* / genetics
Cytoskeleton / metabolism
Disease
Humans
Organ Specificity
Organogenesis*

Abstract

Publication types

MeSH terms

Grants and funding