Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens

Nucleic Acids Res. 1985 Dec 20;13(24):8827-41. doi: 10.1093/nar/13.24.8827.


The primary structures of a cDNA and the genomic DNA of a gene selectively expressed in chronic lymphocytic leukemia were determined. A computer search of the nucleotide sequence data bank identified this gene as the invariant gamma-chain associated with class II histocompatibility antigens. The invariant gamma-chain genomic sequence spans about 11 kilobases, with eight exons and seven introns. Three of the introns contain members of the Alu repeat family. A putative cap site and promoter sequence were identified at the 5' end of the gene. One or two copies of the gene is present in each haploid genome, and no evidence for amplification or polymorphism was obtained.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Bone Marrow / physiology
  • Chromosome Mapping
  • Chromosomes, Human, 4-5
  • DNA Restriction Enzymes / metabolism
  • Genes
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II / genetics*
  • Humans
  • Leukemia, Lymphoid / genetics
  • Leukocytes / physiology
  • Macromolecular Substances
  • RNA, Messenger / genetics
  • Repetitive Sequences, Nucleic Acid


  • HLA-DR Antigens
  • Histocompatibility Antigens Class II
  • Macromolecular Substances
  • RNA, Messenger
  • DNA Restriction Enzymes

Associated data

  • GENBANK/X03339
  • GENBANK/X03340