Pro-inflammatory Cytokines, Biomarkers, Genetics and the Immune System: A Mechanistic Approach of Depression and Psoriasis

Abstract

Objective: To highlight the inflammatory and immunological mechanisms involved in depression and psoriasis.

Methods: A comprehensive literature search was performed in various databases, in total 145 studies were selected.

Results: Depression and psoriasis have an association. Immune mechanisms -the actions of tumor necrosis factor-α, interleukin 1 (IL-1), IL-2, IL-10, IL-22, IL-17, interferon-γ, IL-1β, prostaglandin E2, C-reactive protein, IL-6, and IL-8 etc.-, and some genetic changes are involved.

Conclusions: A possible bidirectional relationship of psoriasis and major depression exists; i.e. the depression leads to psoriasis, and psoriasis leads to depression. We recommend more studies in the future to get a deeper and better understanding about this relationship.

Keywords: Depresión por inflamación; Depresión por psoriasis; Depression psoriasis; Inflamación por psoriasis; Inflammation depression; Inflammation psoriasis; Neurodermatology; Neurodermatología; Psicodermatología; Psoriasis and major depression; Psoriasis y depresión mayor; Psychodermatology.