Evaluation of Quality of Life Using EORTC QLQ-BM22 in Patients with Bone Metastases after Treatment with Magnetic Resonance Guided Focused Ultrasound

Orthop Surg. 2018 Aug;10(3):264-271. doi: 10.1111/os.12383. Epub 2018 Jul 18.


Objective: To reveal the alterations in quality of life (QOL) in bone metastases patients after magnetic resonance guided focused ultrasound (MRgFUS).

Methods: This retrospective study enrolled 26 patients diagnosed with bone metastases. Patients had various primary malignant tumors and tumor lesions in different locations. All patients received MRgFUS for bone metastasis. Each focal spot sonication pulse that was applied to create energy deposition lasted 20 s and was performed at a frequency of 1.05 MHz. The visual analog scale (VAS) was used to measure pain level and the EORTC QLQ-BM22 was applied to evaluate QOL for 12 months. The lower the QLQ-BM22 score, the better the QOL of patients.

Results: The painful site subscale of the EORTC QLQ-BM22 was observed without significant change. Significant reductions in the functional subscales were observed after therapy compared with the baseline. The functional interference was reduced significantly during the first 12 months. From the 2-month time point onwards, the pain characteristics subscale also decreased significantly. VAS scores had decreased by 40.8% 1 month after the operation and had decreased 10.9% compared with VAS scores preoperation. Scores for pain characteristics decreased by 28.8% after the operation and the scores were still down by 10.8% 1 year after the treatment. VAS scores indicated a significant reduction in pain over the course of the research until the 12-month time point follow-up compared with the baseline.

Conclusion: MRgFUS therapy improved the QOL of patients with bone metastasis by relieving bone pain.

Keywords: Bone metastases; Efficacy; MRgFUS; QLQ-BM22; Safety.

Publication types

  • Evaluation Study

MeSH terms

  • Activities of Daily Living
  • Adult
  • Bone Neoplasms / complications
  • Bone Neoplasms / diagnostic imaging
  • Bone Neoplasms / secondary*
  • Bone Neoplasms / therapy*
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Pain / etiology
  • Pain Management / methods
  • Pain Measurement
  • Palliative Care / methods
  • Psychometrics
  • Quality of Life*
  • Radiology, Interventional / methods
  • Retrospective Studies
  • Ultrasonic Therapy / adverse effects
  • Ultrasonic Therapy / methods*