Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells

Jens Verheyen; Alexander Thielen; Nadine Lübke; Miriam Dirks; Marek Widera; Ulf Dittmer; Lambros Kordelas; Martin Däumer; Dorien C M de Jong; Annemarie M J Wensing; Rolf Kaiser; Monique Nijhuis; Stefan Esser

doi:10.1093/cid/ciy565

Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells

Clin Infect Dis. 2019 Feb 1;68(4):684-687. doi: 10.1093/cid/ciy565.

Authors

Affiliations

¹ Institute of Virology, University Hospital, University of Duisburg-Essen.
² Institute of Immunology and Genetics, Kaiserslautern.
³ Institute of Virology, Heinrich-Heine-University, University Hospital, Düsseldorf.
⁴ Department of Bone Marrow Transplantation, University Hospital, University of Duisburg-Essen, Germany.
⁵ Department of Medical Microbiology, Virology, University Medical Center Utrecht, The Netherlands.
⁶ Institute of Virology, University of Cologne.
⁷ Clinic for Dermatology, University Hospital, University of Duisburg-Essen, Germany.

PMID: 30020413
DOI: 10.1093/cid/ciy565

Abstract

Allogeneic stem cell transplantation (alloSCT) of homozygous CCR5 Δ32 stem cells once resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could already be detected before alloSCT.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

HIV / isolation & purification*
HIV / physiology
HIV Infections / therapy*
Humans
Receptors, CCR5 / deficiency
Receptors, CXCR4 / physiology
Stem Cell Transplantation / methods*
Transplantation, Homologous / methods*
Treatment Outcome
Viral Load*
Viral Tropism*

Substances

CCR5 protein, human
CXCR4 protein, human
Receptors, CCR5
Receptors, CXCR4