Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells

Clin Infect Dis. 2019 Feb 1;68(4):684-687. doi: 10.1093/cid/ciy565.


Allogeneic stem cell transplantation (alloSCT) of homozygous CCR5 Δ32 stem cells once resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could already be detected before alloSCT.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • HIV / isolation & purification*
  • HIV / physiology
  • HIV Infections / therapy*
  • Humans
  • Receptors, CCR5 / deficiency
  • Receptors, CXCR4 / physiology
  • Stem Cell Transplantation / methods*
  • Transplantation, Homologous / methods*
  • Treatment Outcome
  • Viral Load*
  • Viral Tropism*


  • CCR5 protein, human
  • CXCR4 protein, human
  • Receptors, CCR5
  • Receptors, CXCR4