Selective serotonin receptor (5-HT3) antagonists block serotonin both peripherally, on gastrointestinal (GI) vagal nerve terminals, and centrally in the chemoreceptor trigger zone. This blockade results in powerful antiemetic effects. 5-HT3 receptor antagonists are FDA-approved for preventing nausea and vomiting in children and adults related to chemotherapy use, radiation therapy, and the effects of postoperative anesthesia. This activity reviews the indications, contraindications, activity, adverse events, and other key elements of antiemetic 5-HT3 receptor antagonists in the clinical setting as relates to the essential points needed by members of an interprofessional team managing the care of patients who can benefit therapeutically from these agents.
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