A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion

Brendan Horton; Stefani Spranger

doi:10.1016/j.immuni.2018.07.001

A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion

Immunity. 2018 Jul 17;49(1):11-13. doi: 10.1016/j.immuni.2018.07.001.

Authors

Brendan Horton¹, Stefani Spranger²

Affiliations

¹ Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
² Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Howard S. and Linda B. Stern Career Development Professor, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: spranger@mit.edu.

Abstract

Pancreatic adenocarcinoma (PDAC) is mostly refractory to immunotherapies. In this issue of Immunity, Li et al. (2018) generate a library of clonal PDAC tumors to examine the tumor-intrinsic features shaping the anti-tumor immune response and find that tumor cell-derived CXCL1 directly blunts T cell infiltration and reduces responsiveness to immunotherapy.

Publication types

Comment

MeSH terms

Adenocarcinoma
Carcinoma, Pancreatic Ductal*
Humans
Immune Evasion
Immunotherapy
Intrinsic Factor
Pancreatic Neoplasms*
Yin-Yang

Substances

Intrinsic Factor

Grants and funding

R00 CA204595/CA/NCI NIH HHS/United States