Getting a Taste for Parasites in the Gut

Immunity. 2018 Jul 17;49(1):16-18. doi: 10.1016/j.immuni.2018.07.002.


How type 2 immune responses are initiated is obscure. Nadjsombati et al. (2018), along with two other studies (Lei et al., 2018; Schneider et al., 2018), show that tuft cells can initiate type 2 responses by recognizing the metabolite succinate produced by intestinal parasites.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2*
  • Intestines
  • Parasites*
  • Succinic Acid
  • Taste


  • Succinic Acid