Histamine-reduced Diet and Increase of Serum Diamine Oxidase Correlating to Diet Compliance in Histamine Intolerance

Eur J Clin Nutr. 2019 Jan;73(1):102-104. doi: 10.1038/s41430-018-0260-5. Epub 2018 Jul 18.


Diagnosis of histamine intolerance (HIT) has been based on low serum diamine oxidase (DAO) values, functional gastrointestinal disorders and improvement of symptoms with a histamine-reduced diet (HRD). In a retrospective analysis of outpatients' charts we identified 101 patients with HIT. After a median of 13 months, a questionnaire was distributed to the patients so that they could be classified into four diet-compliance groups. Calculated with all 101 patients we found an increase of serum DAO values due to a HRD. In the 63 patients that completed the questionnaire, we found that 50 patients had improvement of symptoms or no continuing symptoms. A significant increase of serum DAO levels was found in the patients with strict and occasional diet compliance. Therefore, we demonstrate that a HRD is not only improving symptoms in HIT, but is causing an increase in serum DAO values that correlates with the degree of diet compliance.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amine Oxidase (Copper-Containing) / blood*
  • Diet Therapy / methods*
  • Female
  • Food Hypersensitivity / blood
  • Food Hypersensitivity / diet therapy*
  • Food Hypersensitivity / etiology
  • Histamine / adverse effects*
  • Humans
  • Male
  • Middle Aged
  • Patient Compliance / statistics & numerical data*
  • Retrospective Studies
  • Surveys and Questionnaires
  • Treatment Outcome
  • Young Adult


  • Histamine
  • Amine Oxidase (Copper-Containing)