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. 2018 Sep;42(10):1423-1431.
doi: 10.1002/cbin.11034. Epub 2018 Jul 27.

Glycine Receptors Are Involved in Hippocampal Neuronal Damage Caused by Oxygen-Glucose Deficiency

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Glycine Receptors Are Involved in Hippocampal Neuronal Damage Caused by Oxygen-Glucose Deficiency

Iryna Lushnikova et al. Cell Biol Int. .

Abstract

Glycine receptors (GlyRs) belong to the family of ligand-gated cys-loop receptors and effectuate fast inhibitory neurotransmission in central nervous system (CNS). They are involved in numerous physiological processes, such as movement, respiration, and processing of sensory information, as well as in regulation of neuronal excitability in different brain regions. GlyRs play important role in the maintenance of excitatory/inhibitory balance in the hippocampus and participate in the development of various brain pathologies. In the present study, we have examined a surface expression of GlyRs by pyramidal neurons and astrocytes in control and after 30 min of oxygen-glucose deprivation (OGD) in the organotypic culture of hippocampal slices. Our investigation has demonstrated a decrease in GlyR-positive staining associated with pyramidal neurons and relative stability of GlyRs expression at the surface of astrocytes 4 hs after OGD. These data indicate that GlyRs dysfunction may represent a significant additional factor leading to enhanced neuronal damage induced by OGD. Pharmacological modulation of GlyRs is a promising venue of research for the correction of negative consequences of oxygen-glucose deficiency.

Keywords: GlyRs; astroglia; hippocampus; neurodegeneration; pyramidal neurons.

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