Developmental progress of CRISPR/Cas9 and its therapeutic applications for HIV-1 infection

Rev Med Virol. 2018 Sep;28(5):e1998. doi: 10.1002/rmv.1998. Epub 2018 Jul 19.

Abstract

The CRISPR/Cas9 system has been developed as a powerful tool for targeted gene editing. As a result of technical enhancements in recent years, this technology has become the method of choice for efficiently modifying targeted HIV-1 genome efficiently as part of HIV therapy. CRISPR can be modified to target specific sequences that Cas9 then cuts. In this article, we outline the development of the CRISPR/Cas9 system. We also show how this technology can be used for the prevention and treatment of HIV-1 infection. Optimistically, this technology promises to make a significant impact on the fight against HIV-1 in the future.

Keywords: CCR5; CRISPR/Cas9; HIV-1 infection; gene editing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CRISPR-Cas Systems*
  • Gene Editing
  • Genetic Engineering
  • Genetic Therapy* / methods
  • HIV Infections / genetics*
  • HIV Infections / therapy
  • HIV Infections / virology*
  • HIV-1 / genetics*
  • Humans