Low- Q Bicelles Are Mixed Micelles

J Phys Chem Lett. 2018 Aug 2;9(15):4469-4473. doi: 10.1021/acs.jpclett.8b02079. Epub 2018 Jul 25.


Bicelles are used in many membrane protein studies because they are thought to be more bilayer-like than micelles. We investigated the properties of "isotropic" bicelles by small-angle neutron scattering, small-angle X-ray scattering, fluorescence anisotropy, and molecular dynamics. All data suggest that bicelles with a q value below 1 deviate from the classic bicelle that contains lipids in the core and detergent in the rim. Thus not all isotropic bicelles are bilayer-like.