Prediction of major depressive episodes and suicide-related ideation over a 3-year interval among Japanese undergraduates

PLoS One. 2018 Jul 19;13(7):e0201047. doi: 10.1371/journal.pone.0201047. eCollection 2018.

Abstract

Background: Suicide has been a leading cause of death among young adult populations in Japan. The aim of this study was to predict major depressive episodes (MDEs) and suicide-related ideation among university students using the Patient Health Questionnaire-9 (PHQ-9) and the Temperament and Character Inventory (TCI).

Methods: The subjects were 2194 university students who completed the PHQ-9 and TCI in the 1st year (T1) and the PHQ-9 in the 4th year (T2) of university. Multiple logistic regression analysis was performed to predict MDEs and suicide-related ideation at T2. Moreover, recursive partitioning analyses were conducted to reveal the future risk of MDEs and suicide-related ideation.

Results: The multiple logistic regression analyses of MDEs and suicide-related ideation at T2 revealed that depressive episodes, suicide-related ideation, and low self-directedness(SD) scores at T1 were significant predictors. The area under the curve of the model for MDEs was 0.858 and that for suicide-related ideation was 0.741. The recursive partitioning analyses revealed that a PHQ-9 summary score ≥15 at T1 predicted a high risk of MDEs at T2 and that both a PHQ-9 summary score ≥5 and a PHQ-9 #9 score ≥1 predicted a high risk of suicide-related ideation at T2.

Conclusions: MDEs, suicide-related ideation, and low SD scores are significant predictors of future MDEs and suicide-related ideation.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Character
  • Depressive Disorder, Major / diagnosis*
  • Depressive Disorder, Major / epidemiology
  • Depressive Disorder, Major / psychology
  • Female
  • Humans
  • Japan / epidemiology
  • Male
  • Personality / physiology*
  • Personality Inventory
  • Prospective Studies
  • Psychiatric Status Rating Scales
  • Risk Factors
  • Students / psychology*
  • Suicidal Ideation*
  • Suicide, Attempted / psychology*
  • Surveys and Questionnaires
  • Temperament
  • Universities
  • Young Adult

Grants and funding

This study was supported by Japan Society for Promotion of Science KAKENHI Grant Number JP15K09853 (SA).